RED CELLS, IRON, AND ERYTHROPOIESIS Impaired FANCD2 monoubiquitination and hypersensitivity to camptothecin uniquely characterize Fanconi anemia complementation group M
نویسندگان
چکیده
1Division of Experimental Hematology and Cancer Biology, Cincinnati Children’s Research Foundation, University of Cincinnati College of Medicine, OH; 2Department of Clinical Genetics, VU University Medical Centre, Amsterdam, The Netherlands; 3Division of Molecular Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands; and 4Department of Toxicogenetics, Leiden University Medical Center, Leiden, The Netherlands
منابع مشابه
Increased formation of early-labeled bilirubin in rats with iron deficiency anemia: evidence for ineffective erythropoiesis.
I RON DEFICIENCY ANEMIA is usually characterized by erythroid hyperplasia of the bone marrow, but impaired net synthesis of hemoglobin. This association suggests that the anemia may be due in part to ineffective erythropoiesis, i.e., destruction of immature red cells in the bone marrow or soon after their release into the circulation. Morphologic observations are also compatible with ineffectiv...
متن کاملErythropoiesis: insights into pathophysiology and treatments in 2017
Erythropoiesis is a tightly-regulated and complex process originating in the bone marrow from a multipotent stem cell and terminating in a mature, enucleated erythrocyte. Altered red cell production can result from the direct impairment of medullary erythropoiesis, as seen in the thalassemia syndromes, inherited bone marrow failure as well as in the anemia of chronic disease. Alternatively, in ...
متن کاملAltered erythropoiesis and iron metabolism in carriers of thalassemia.
The thalassemia syndromes (α- and β-thalassemia) are the most common and frequent disorders associated with ineffective erythropoiesis. Imbalance of α- or β-globin chain production results in impaired red blood cell synthesis, anemia, and more erythroid progenitors in the blood stream. While patients affected by these disorders show definitive altered parameters related to erythropoiesis, the r...
متن کاملAnemia of chronic disease: illness or adaptive mechanism.
The anemia of chronic disease (ACD) is the most prevalent anemia after iron deficiency anemia. It is associated with infectious, inflammatory and neoplastic disease. ACD is a medical condition caused by the release of cytokines which mediate inflammatory and immune response (tumor necrosis factor, interleukins 1 and 6, and interferon). Abnormal iron metabolism with iron trapping in reticuloendo...
متن کاملRed blood cell distribution width as a link between ineffective erythropoiesis and chronic inflammation in heart failure.
for increasing oxygen delivery to peripheral tissues by increasing oxygen carrying capacity and total blood volume. Iron deficiency is prevalent in cyanotic patients because of the increased iron demand resulting from secondary erythrocytosis.10 In cyanotic ACHD, iron deficiency anemia is reported to relate to cerebrovascular events.11 Thus, iron deficiency and ineffective erythropoiesis are li...
متن کامل